Depression How It Affect You

In: Philosophy and Psychology

Submitted By kibran2172
Words 2441
Pages 10
sychologyHow depression affects people

Kim Branim
Psychology 326 Sonja Bethune
October 16, 2012

Introduction
This study was design to find loci major depression via linkage analysis of a large sibling pair sample. Depressions in twins and families have been shown moderate high.
“However the gene that caused depression had not been detected says” Lewis Cathryn but Gerome Breen “says that Chromosome3 it a link to severe depression. Breen study took 417 families with 479 concordant sibling pairs to perform genome-wide linkage analysis. Breen used the first wave of families, suggestive and modest suggestive and modest evidence for linkage was found on chromosomes 1p36, 12q, 13q, and 15q. The peaks on chromosomes 12q and 15q also showed evidence for linkage in other samples (8-10). In the present study, we report linkage analysis results using an expanded sample that includes 325 additional families contributing 474 sibling pairs, resulting in a total of 971 concordant sibling pairs with recurrent depression. The total sample also consisted of 118 discordant sibling pairs and 12 unaffected sibling pairs. Linkage can be detected when heterogeneity and error in phenotype are decreased. Also for depression, reliability is improved by focusing on severe cause ad indexed by symptom count or impairment. (Breen,2011)

. Literature review The article name is Genome-Wide Association Study of Major Recurrent Depression in the U.K. Population. The Studies of major depression in twins and families have shown moderate to high heritability, but extensive molecular studies have failed to identify susceptibility genes convincingly. To detect genetic variants contributing to major depression, the authors performed a genome-wide association study using 1,636 cases of depression ascertained in the U.K. and 1,594 comparison subjects screened negative for psychiatric…...

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