Hydrocephalus

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Submitted By dchicks
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Hydrocephalus

Hydrocephalus
Hydrocephalus is an anomaly which origins have been linked to both genetic and environmental factors. Saladin, (2007) has defined hydrocephalus as an abnormal accumulation of central spinal fluid (CSF) in the brain usually as a result of a blockage in the CSF flow and the subsequent reabsorption. The rate of occurrence of hydrocephalus varies by whom is asked; there are not any national registries therefore there is not a data base that can accurately depict a real number of people afflicted with this anomaly. Instances of hydrocephalus are not all associated with genetics, some other factors that have been documented are: congenital malformations, intercerebral hemorrhage, infection and maternal alcohol abuse. Two article will be discussed in the paper; one article is dedicated to genetics while the second article discusses environmental factors that have been associated with hydrocephalus.
Article 1 Genetics of human hydrocephalus
The article discusses that evidence is mounting that genetic factors play a role in the “pathogenesis of hydrocephalus”. Hydrocephalus has two forms; acquired and inherited. There are several documented instanced of genetic involved in hydrocephalus in animals, but the documentation that has been gathered to date is not as substantial in human hydrocephalus. “Hydrocephalus is considered complex and has multifactorial neurological defects.” It is believed that one of the possible causes is related to protein and signal disruption during the early development of the fetal brain. The article covers the documentation obtained on animals and believes that this is an initial phase in human research, but at this time human research has not developed into a significant number of studies. To better understand hydrocephalus and to develop better research tools, a large and diverse research study group will have…...

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