Tuberculosis

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Sometimes, TB goes undetected in those that are immunologically compromised. They frequently show false-negative results during a Mantouxreading. This is because the immune system is not functioning in its usual capacity & cannot mount a defense against the bacteria. This defense mechanism is needed to produce the localized inflammation at the spot of the injection. Those who have highly active TB may also show a negative test result but, at that level of activity, the signs and symptoms of the infection would already be obvious for some time & the patient is likely already undergoing treatment. Erin Miller Thursday night class. divide quicker than those who have been maintaining the bacteria for a period of time. When they become infected, it allows the bacteria to spread more quickly. If the tubercles become unable to contain the infection and the bacteria is able to "deactivate" the cytokines, the macrophages may begin to reabsorb the cytokines. The cytokines original structure is now mutated and can provoke two responses from the macrophages. The first, is that the macrophages do nothing to fight the infection. The second, is that the macrophages recognize normal flora as foreign and begin to attack, allowing for quicker MTB infection. Since the macrophages now do not recognize the MTB as foreign, once infected, they stop destroying those cells. The combination of rapid bacterial infection & the phagocytosisof normal flora by the macrophages produce chronic inflammation of the lungs. If these things take place, stage four begins. Erin Miller Thursday night class. In stage five, the centers of the tubercles liquify, fueling MTB growth and allowing the organism to begin rapidly multiplying extracellularly. Eventually the walls of the nearby bronchi become necrotic and rupture. This forms a cavity in the lung and allows the MTB to spill into…...

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