Vitamin B6 in Wheat

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Vitamin B6 is a water soluble vitamin present in many forms in human diet. Vitamin B6 has an essential role as cofactor for many metabolic enzymes (1). Vitamin b6 is a complex of six vitamers pyridoxal, pyridoxamine, pyridoxine, pyradoxamine 5-phosphate, pyridoxine 5 phosphate and pyridoxal 5 phosphate which is active form as human vitamin. Human have to take vitamin B6 from diet because they can’t synthesize it DE novo (2). Vitamin B6 has been known to have important role as antioxidant and have properties to increase stress tolerance in plants and in humans it is closely associated with functions of nervous, immune, and endocrine systems (2, 3). It also possesses a role in metabolic process of proteins, lipids and carbohydrates. Its deficiency is associated with cardiovascular disorders and neurological diseases and lead to infant abnormalities which are increasing in Asian countries and Pakistanis being in south Asian population have quite high rates of coronary heart disease (4), As abundance of this vitamin in edible parts of plants is insufficient to meet recommended daily allowance i.e. 1-3 mg/day(5).
Wheat (Triticum aestivum) is the most important and considered cereal crop for major part of global population. Wheat is considered to be chief crop in Pakistan, contributing around 10.3 % to agricultural sector (6). Globally wheat provides around 55% carbohydrate, and 20% of calories consumed worldwide (7). With a huge progress in metabolic engineering of crops in Pakistan too, wheat metabolic engineering is now being done for various micro and macro nutrients and to increase its agronomic properties so using this approach vitamin B6 enhancement by introduction of pyridoxine gene in wild type cultivar of wheat is an opportunity with bright future to combat vitamin B6 deficiency which is leading to increase cardiovascular and neurological disorders.

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